bio-TIE Lab | Mohammad J. Mirzaali

Publications

Selected Publications

Click any paper to expand details. Papers marked Nature are published in Nature-family journals.

2026

Elasto-optic transduction in polymer-cladded silicon microring arrays for real-time 2D force mapping Open Access

Safarloo S, Erdogan RT, Westerveld WJ, Zadpoor AA, Steeneken PG, Mirzaali MJ

Optics Express 34(4), 6721â6735 (2026)

Silicon microring resonator arrays with polymer cladding for real-time two-dimensional force mapping via elasto-optic transduction. The sensor arrays achieve a force resolution down to 12 ÂµN, demonstrated with a five-ring linear array and a 10Ã5 two-dimensional array at 15 Âµm pitch â enabling high-resolution tactile sensing for biomedical and robotic applications.

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2025

Non-planar additive manufacturing with hydrogels: a review of flow control and toolpath strategies Open Access

van der Valk, P.C.W.M., Mirzaali, M.J.*

npj Soft Matter 1, 5 (2025)

A comprehensive review of non-planar additive manufacturing strategies using hydrogel-based inks, covering flow control mechanisms and toolpath optimization for complex 3D bioprinting applications including extrusion control, slicing algorithms, multi-axis systems, and support-free strategies.

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Magnetic cells and scaffolds for bone tissue engineering Adv. Science

San Segundo, E.C., Mirzaali, M.J.*, Fratila-Apachitei, L.E., Zadpoor, A.A.

Advanced Science 12(41), e2410094 (2025)

Investigation of magnetic cells and scaffolds as a novel approach for bone tissue engineering, exploring how magnetic stimulation can enhance osteogenic differentiation and scaffold integration for next-generation orthopedic implants.

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Two-photon polymerization based 4D printing of poly(N-isopropylacrylamide) hydrogel microarchitectures for reversible shape morphing Open Access

Yarali, E., Mubeen, A.A., Cussen, K., van Zanten, L., Moosabeiki, V., Zadpoor, A.A., Accardo, A., Mirzaali, M.J.*

Scientific Reports 15, 21549 (2025)

Programmable shape-morphing 3D microarchitectures fabricated using two-photon polymerization (2PP) of temperature-responsive pNIPAM hydrogel, capable of rapid and reversible actuation. Enables precise, non-invasive, controllable deformation for soft robotics and microfluidic systems.

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Additively manufactured shape-morphing implants for the treatment of acetabular defects

Moosabeiki, V., Leeflang, M.A., Gerbers, J.G., de Jong, P.H., Broekhuis, D., Agarwal, Y., Ganesen, J.N., Kaptein, B.L., Nelissen, R.G.H.H., Mirzaali, M.J.*, Zadpoor, A.A.

Acta Biomaterialia 2025 â in press (July 2025)

Design, additive manufacturing, and evaluation of shape-morphing porous implants with kinematic structures for three acetabular defect types (posterior wall, cranial-posterior, central-posterior) in revision total hip arthroplasty. Demonstrates superior defect filling and mechanical stability.

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High-performance 3D printed mechanically interlocked soft-hard interfaces of hydrogels and polylactide

Kunkels, L., Cruz SaldÃvar, M., Putra, N.E., Pitta Kruize, C., Panahkhahi, S., Leeflang, M.A., Fratila-Apachitei, L.E., Zadpoor, A.A., Mirzaali, M.J.*

Advanced Materials Technologies 10, 2401081 (2025)

Development of mechanically interlocked interfaces between hydrogels and polylactide using multi-material 3D printing, achieving high-performance combination of mechanical performance and biocompatibility for Hard-soft interface applications.

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2024

Suppressing torsional buckling in auxetic meta-shells Nature Comm. Open Access

Ghorbani, A., Mirzaali, M.J., Roebroek, T., Coulais, C., Bonn, D., van der Linden, E., Habibi, M.

Nature Communications 15, 6999 (2024)

A novel approach to suppress torsional buckling instabilities in auxetic meta-shells by combining auxeticity and orthotropy in cylindrical metamaterial shells. The work opens new design pathways for mechanically robust lightweight structures with negative Poisson's ratio under large twist angles.

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Curvature tuning through defect-based 4D printing Open Access

Moosabeiki, V., Yarali, E., Ghalayaniesfahani, A., Callens, S.J., van Manen, T., Accardo, A., Ghodrat, S., Bico, J., Habibi, M., Mirzaali, M.J.*, Zadpoor, A.A.

Communications Materials 5, 10 (2024)

A design approach that harnesses anisotropic deformation and micro-defect formation during fused deposition modeling to create tailor-made curved geometries from initially 2D flat disks. Size and distribution of imperfections can be controlled by varying printing speed and number of printed materials. Featured in Springer Nature's "Behind the Paper" series.

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4D Printing for Biomedical Applications Adv. Materials

Yarali, E., Mirzaali, M.J.* [joint first author], Ghalayaniesfahani, A., Accardo, A., Diaz-Payno, P.J., Zadpoor, A.A.

Advanced Materials 36(31), 2402301 (2024)

A comprehensive overview of 4D printing for biomedical applications, covering shape-memory polymers, hydrogels, and composite materials that respond to biological and physical stimuli for stents, occluders, microneedles, drug delivery systems, wound closures, and implantable medical devices.

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Multi-material 3D printing of functionally graded soft-hard interfaces for enhancing mandibular kinematics of temporomandibular joint replacement prostheses Open Access

Moosabeiki, V., Khan, A., Cruz SaldÃvar, M., Van Paepegem, W., Jonker, B.P., Wolvius, E.B., â¦Mirzaali, M.J.*, Zadpoor, A.A.

Communications Materials 5, 226 (2024)

Development of functionally graded soft-hard interface prostheses for temporomandibular joint replacement. Five FGM designs â including hard, hard-soft, and three gradual transitions â were evaluated, significantly improving mandibular kinematics and reducing joint reaction forces.

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Orthopedic meta-implants Open Access

Mirzaali, M.J., Zadpoor, A.A.

APL Bioengineering 8, 010901 (2024)

A forward-looking perspective on orthopedic meta-implants â next-generation implants harnessing mechanical metamaterial principles to achieve programmable stiffness, auxeticity, and shape-morphing properties not found in conventional implants. Published open access under Creative Commons (CC BY).

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Deep learning for size-agnostic inverse design of random-network 3D printed mechanical metamaterials Adv. Materials Open Access

Pahlavani, H., Tsifoutis-Kazolis, K., SaldÃvar, M.C., Mody, P., Zhou, J., Mirzaali, M.J.*, Zadpoor, A.A.

Advanced Materials 36(6), 2303481 (2024)

Deep-DRAM â a size-agnostic inverse design framework combining deep learning and conditional variational autoencoders â generates random-network lattice structures with predefined elastic properties and predefined dimensions. Featured in SciTechDaily and other media as a breakthrough in AI-driven metamaterial design.

ð DOI ð PDF (TU Delft Repository)

2023

Bioinspired rational design of bi-material 3D printed soft-hard interfaces Nature Comm. Open Access

SaldÃvar, M.C., Tay, E., Issakidou, A., Moosabeiki, V., Fratila-Apachitei, L.E., Doubrovski, E.L., Mirzaali, M.J.*, Zadpoor, A.A.

Nature Communications 14, 7919 (2023)

A bioinspired design framework for bi-material soft-hard interfaces based on triply periodic minimal surfaces and collagen-like triple helices. Biomimetic architectural strategies dramatically improve interface strength and energy absorption in 3D-printed composites mimicking natural tissue junctions such as bone-tendon connections.

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Rational positioning of 3D-printed voxels to realize high-fidelity multifunctional soft-hard interfaces

SaldÃvar, M.C., Salehi, S., Veeger, R.P.E., Fenu, M., Cantamessa, A., Klimopoulou, M., â¦Mirzaali, M.J.*, Zadpoor, A.A.

Cell Reports Physical Science 4, 101567 (2023)

A voxel-level design strategy for multi-material 3D printing that enables rational positioning of material building blocks to achieve high-fidelity replication of soft-hard interfaces with multiple simultaneous functional targets.

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Earlier Highlights

Design, material, function, and fabrication of metamaterials Open Access

Zadpoor, A.A., Mirzaali, M.J.*, Valdevit, L, Hopkins, J.B.

APL Materials 11, 020401 (2023) â Special Issue Editor

Editorial and overview for a landmark special issue on metamaterials, covering design principles, material selection, functional targets, and fabrication strategies â providing a comprehensive roadmap for the field.

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Deep learning for the rare-event rational design of 3D printed multi-material mechanical metamaterials Open Access

Pahlavani, H., SaldÃvar, M.C., Zhou, J., Mol, J.M.C., Mirzaali, M.J.*, Zadpoor, A.A.

Communications Materials 3, 46 (2022)

Deep learning framework for rare-event identification in multi-material 3D printed mechanical metamaterials â discovering extreme-property designs that conventional sampling methods would miss. Explores hard/soft phase distributions across planar lattice architectures.

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Additive Manufacturing of Biomaterials â Design Principles and Their Implementation Open Access

Mirzaali, M.J.*, Moosabeiki, V., Rajaei Harandi, S., Zhou, J., Zadpoor, A.A.

Materials 15(15), 5457 (2022)

Comprehensive review of design principles for additive manufacturing of biomaterials across metals, polymers, and ceramics. Covers library-based design, topology optimisation, bioinspired design, and meta-biomaterials. One of the most-cited and most-viewed review articles in the journal.

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Ultra-programmable buckling-driven soft cellular mechanisms Open Access

Janbaz, S., Bobbert, F.S.L., Mirzaali, M.J., Zadpoor, A.A.

Materials Horizons 6, 1138â1147 (2019)

Multi-material buckling-driven metamaterials with high programmability, demonstrating double-side buckling modes alongside conventional instability modes. Applications include force switches, kinematic controllers, and pick-and-place end-effectors for soft robotics. Featured by the Royal Society of Chemistry.

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Action-at-a-distance metamaterials: Distributed local actuation through far-field global forces Open Access

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Mohammad J.
Mirzaali

Bridging Biology & Engineering

Editorial Positions

Research Interests

Startups & Innovation

Roylinx

Morphly

OrthoClay

Awards

Our Research Areas

Hard-Soft Interface Engineering

Additive Manufacturing & 4D Printing

Mechanical Metamaterials

Bone Mechanics & Implant Design

Bioinspired & Sustainable Materials

Tissue Interface Engineering

Selected Publications

Mohammad J.Mirzaali

Bridging Biology & Engineering

Editorial Positions

Research Interests

Startups & Innovation

Roylinx

Morphly

OrthoClay

Awards

Our Research Areas

Hard-Soft Interface Engineering

Additive Manufacturing & 4D Printing

Mechanical Metamaterials

Bone Mechanics & Implant Design

Bioinspired & Sustainable Materials

Tissue Interface Engineering

Selected Publications

Mohammad J.
Mirzaali