bio-TIE Lab

Mohammad J.
Mirzaali

Department of Biomechanical Engineering · TU Delft, The Netherlands

Leading research at the intersection of biomimetics, additive manufacturing, and tissue interface engineering. Our lab designs next-generation bio-inspired materials and implants that bridge the gap between hard and soft biological tissues.

🔬 Metamaterials 🦴 Biomechanics 🏗️ Additive Manufacturing 🤖 AI-Assisted Design 🧬 Tissue Engineering

Bridging Biology & Engineering

Director of the bio-TIE (BIOmimetic Tissue InterfacEs) Lab — a multidisciplinary research group at the intersection of biomechanics, advanced manufacturing, and bioinspired design.

Editorial Positions

2024
Editorial Board Member
Journal of Discover Mechanical Engineering, Springer Nature
2024
Early Career Board Member
Journal of Applied Materials Today, Elsevier
2022
Co-guest Editor
Journal of Functional Biomaterials — 'Advanced 3D printing Biomaterials'
2021
Co-guest Editor
APL Materials — 'Design, Material, Function, and Fabrication of Metamaterials'

Research Interests

Mechanics of Interfaces Additive Manufacturing Biomaterials Biomechanics Biomimetics Bone Mechanics Damage Mechanics Designer Materials Finite Element Method Fracture Mechanics Regenerative Medicine Tissue Interface Engineering Metamaterials 4D Printing

Our Research Areas

The bio-TIE Lab investigates the mechanics and design of tissue interfaces using advanced manufacturing and computational tools.

🔗

Hard-Soft Interface Engineering

Designing bio-inspired interfaces between hard and soft biological tissues using multi-material 3D printing and biomimetic architectures. Our work on functionally graded interfaces addresses critical challenges in implant integration.

Additive Manufacturing & 4D Printing

Pioneering multi-material and 4D printing techniques for shape-morphing implants, biodegradable scaffolds, and programmable metamaterials. Includes non-planar 3D printing, two-photon polymerization, and bitmap composite strategies.

🧠

Mechanical Metamaterials

Engineering auxetic, buckling-driven, and action-at-a-distance metamaterials with programmable mechanical properties. Leveraging AI and machine learning for inverse design and optimization.

🦴

Bone Mechanics & Implant Design

Patient-specific implants for orthopedics, mandibular reconstruction, and spinal cage design. Combining finite element modeling, topology optimization, and clinical biomechanics.

🌿

Bioinspired & Sustainable Materials

Drawing inspiration from natural structures (bone, roots, shells) to design next-generation biomaterials. Includes food-waste biomaterials, sustainable inks for 3D printing, and biodegradable implants.

🔬

Tissue Interface Engineering

Engineering the transition zone between dissimilar biological tissues — bone-cartilage, bone-tendon, implant-bone — through graded materials, hierarchical microarchitectures, and cell-guiding scaffolds. The core mission of the bio-TIE Lab.

Selected Publications

Click any paper to expand details.

2026
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Multi-material interface printing of a magneto-responsive hydrogel scaffold with tuned stiffness
San Segundo, E.C., Kunkels, L.B., Safarloo, S., van Zanten, L., Fratila-Apachitei, L.E., Zadpoor, A.A., Mirzaali, M.J.
Applied Materials Today 50, 103240 (2026)

Development of 3D-printed, multi-material magneto-responsive hydrogel scaffolds with tuned stiffness for osteochondral tissue engineering. The study demonstrates magnetorheological behavior and optimal gelatin-alginate-iron oxide composite formulations for enhanced scaffold performance.

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3D printed multi-material scaffolds: integrating bioceramic with metal for enhanced bone scaffold performance
Panahkhahi, S., Zwart, M.H., Moosabeiki, V., Kunkels, L.B., Leeflang, M.A., Klimopoulou, M., Putra, N.E., Fratila-Apachitei, L.E., Zhou, J., Mirzaali, M.J., Zadpoor, A.A.
Materialia 102748 (2026)

Multi-material bone scaffolds combining Ti6Al4V and akermanite bioceramic through direct ink writing. The study demonstrates enhanced mechanical properties and osteo-inductive potential through core-shell scaffold design integrating the mechanical strength of titanium with bioactive ceramic properties.

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Elasto-optic transduction in polymer-cladded silicon microring arrays for real-time 2D force mapping Open Access
Safarloo S, Erdogan RT, Westerveld WJ, Zadpoor AA, Steeneken PG, Mirzaali MJ
Optics Express 34(4), 6721–6735 (2026)

Silicon microring resonator arrays with polymer cladding for real-time two-dimensional force mapping via elasto-optic transduction. The sensor arrays achieve a force resolution down to 12 µN, demonstrated with a five-ring linear array and a 10×5 two-dimensional array at 15 µm pitch — enabling high-resolution tactile sensing for biomedical and robotic applications.

2025
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Non-planar additive manufacturing with hydrogels: a review of flow control and toolpath strategies Open Access
van der Valk, P.C.W.M., Mirzaali, M.J.*
npj Soft Matter 1, 5 (2025)

A comprehensive review of non-planar additive manufacturing strategies using hydrogel-based inks, covering flow control mechanisms and toolpath optimization for complex 3D bioprinting applications including extrusion control, slicing algorithms, multi-axis systems, and support-free strategies.

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Magnetic cells and scaffolds for bone tissue engineering Adv. Science
San Segundo, E.C., Mirzaali, M.J.*, Fratila-Apachitei, L.E., Zadpoor, A.A.
Advanced Science 12(41), e2410094 (2025)

Investigation of magnetic cells and scaffolds as a novel approach for bone tissue engineering, exploring how magnetic stimulation can enhance osteogenic differentiation and scaffold integration for next-generation orthopedic implants.

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Two-photon polymerization based 4D printing of poly(N-isopropylacrylamide) hydrogel microarchitectures for reversible shape morphing Open Access
Yarali, E., Mubeen, A.A., Cussen, K., van Zanten, L., Moosabeiki, V., Zadpoor, A.A., Accardo, A., Mirzaali, M.J.*
Scientific Reports 15, 21549 (2025)

Programmable shape-morphing 3D microarchitectures fabricated using two-photon polymerization (2PP) of temperature-responsive pNIPAM hydrogel, capable of rapid and reversible actuation. Enables precise, non-invasive, controllable deformation for soft robotics and microfluidic systems.

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Additively manufactured shape-morphing implants for the treatment of acetabular defects
Moosabeiki, V., Leeflang, M.A., Gerbers, J.G., de Jong, P.H., Broekhuis, D., Agarwal, Y., Ganesen, J.N., Kaptein, B.L., Nelissen, R.G.H.H., Mirzaali, M.J.*, Zadpoor, A.A.
Acta Biomaterialia 2025 — in press (July 2025)

Design, additive manufacturing, and evaluation of shape-morphing porous implants with kinematic structures for three acetabular defect types (posterior wall, cranial-posterior, central-posterior) in revision total hip arthroplasty. Demonstrates superior defect filling and mechanical stability.

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High-performance 3D printed mechanically interlocked soft-hard interfaces of hydrogels and polylactide
Kunkels, L., Cruz Saldívar, M., Putra, N.E., Pitta Kruize, C., Panahkhahi, S., Leeflang, M.A., Fratila-Apachitei, L.E., Zadpoor, A.A., Mirzaali, M.J.*
Advanced Materials Technologies 10, 2401081 (2025)

Development of mechanically interlocked interfaces between hydrogels and polylactide using multi-material 3D printing, achieving high-performance combination of mechanical performance and biocompatibility for hard-soft interface applications.

2024
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Suppressing torsional buckling in auxetic meta-shells Open Access
Ghorbani, A., Mirzaali, M.J., Roebroek, T., Coulais, C., Bonn, D., van der Linden, E., Habibi, M.
Nature Communications 15, 6999 (2024)

A novel approach to suppress torsional buckling instabilities in auxetic meta-shells by combining auxeticity and orthotropy in cylindrical metamaterial shells. The work opens new design pathways for mechanically robust lightweight structures with negative Poisson's ratio under large twist angles.

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Curvature tuning through defect-based 4D printing Open Access
Moosabeiki, V., Yarali, E., Ghalayaniesfahani, A., Callens, S.J., van Manen, T., Accardo, A., Ghodrat, S., Bico, J., Habibi, M., Mirzaali, M.J.*, Zadpoor, A.A.
Communications Materials 5, 10 (2024)

A design approach that harnesses anisotropic deformation and micro-defect formation during fused deposition modeling to create tailor-made curved geometries from initially 2D flat disks. Size and distribution of imperfections can be controlled by varying printing speed and number of printed materials. Featured in Springer Nature's "Behind the Paper" series.

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4D Printing for Biomedical Applications Adv. Materials
Yarali, E., Mirzaali, M.J.* [joint first author], Ghalayaniesfahani, A., Accardo, A., Diaz-Payno, P.J., Zadpoor, A.A.
Advanced Materials 36(31), 2402301 (2024)

A comprehensive overview of 4D printing for biomedical applications, covering shape-memory polymers, hydrogels, and composite materials that respond to biological and physical stimuli for stents, occluders, microneedles, drug delivery systems, wound closures, and implantable medical devices.

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Multi-material 3D printing of functionally graded soft-hard interfaces for enhancing mandibular kinematics of temporomandibular joint replacement prostheses Open Access
Moosabeiki, V., Khan, A., Cruz Saldívar, M., Van Paepegem, W., Jonker, B.P., Wolvius, E.B., …Mirzaali, M.J.*, Zadpoor, A.A.
Communications Materials 5, 226 (2024)

Development of functionally graded soft-hard interface prostheses for temporomandibular joint replacement. Five FGM designs — including hard, hard-soft, and three gradual transitions — were evaluated, significantly improving mandibular kinematics and reducing joint reaction forces.

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Orthopedic meta-implants Open Access
Mirzaali, M.J., Zadpoor, A.A.
APL Bioengineering 8, 010901 (2024)

A forward-looking perspective on orthopedic meta-implants — next-generation implants harnessing mechanical metamaterial principles to achieve programmable stiffness, auxeticity, and shape-morphing properties not found in conventional implants. Published open access under Creative Commons (CC BY).

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Deep learning for size-agnostic inverse design of random-network 3D printed mechanical metamaterials Adv. Materials Open Access
Pahlavani, H., Tsifoutis-Kazolis, K., Saldívar, M.C., Mody, P., Zhou, J., Mirzaali, M.J.*, Zadpoor, A.A.
Advanced Materials 36(6), 2303481 (2024)

Deep-DRAM — a size-agnostic inverse design framework combining deep learning and conditional variational autoencoders — generates random-network lattice structures with predefined elastic properties and predefined dimensions. Featured in SciTechDaily and other media as a breakthrough in AI-driven metamaterial design.

2023
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Bioinspired rational design of bi-material 3D printed soft-hard interfaces Open Access
Saldívar, M.C., Tay, E., Issakidou, A., Moosabeiki, V., Fratila-Apachitei, L.E., Doubrovski, E.L., Mirzaali, M.J.*, Zadpoor, A.A.
Nature Communications 14, 7919 (2023)

A bioinspired design framework for bi-material soft-hard interfaces based on triply periodic minimal surfaces and collagen-like triple helices. Biomimetic architectural strategies dramatically improve interface strength and energy absorption in 3D-printed composites mimicking natural tissue junctions such as bone-tendon connections.

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Rational positioning of 3D-printed voxels to realize high-fidelity multifunctional soft-hard interfaces
Saldívar, M.C., Salehi, S., Veeger, R.P.E., Fenu, M., Cantamessa, A., Klimopoulou, M., …Mirzaali, M.J.*, Zadpoor, A.A.
Cell Reports Physical Science 4, 101567 (2023)

A voxel-level design strategy for multi-material 3D printing that enables rational positioning of material building blocks to achieve high-fidelity replication of soft-hard interfaces with multiple simultaneous functional targets.

Earlier Highlights
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Design, material, function, and fabrication of metamaterials Open Access
Zadpoor, A.A., Mirzaali, M.J.*, Valdevit, L., Hopkins, J.B.
APL Materials 11, 020401 (2023) — Special Issue Editor

Editorial and overview for a landmark special issue on metamaterials, covering design principles, material selection, functional targets, and fabrication strategies — providing a comprehensive roadmap for the field.

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Deep learning for the rare-event rational design of 3D printed multi-material mechanical metamaterials Open Access
Pahlavani, H., Saldívar, M.C., Zhou, J., Mol, J.M.C., Mirzaali, M.J.*, Zadpoor, A.A.
Communications Materials 3, 46 (2022)

Deep learning framework for rare-event identification in multi-material 3D printed mechanical metamaterials — discovering extreme-property designs that conventional sampling methods would miss. Explores hard/soft phase distributions across planar lattice architectures.

+
Additive Manufacturing of Biomaterials — Design Principles and Their Implementation Open Access
Mirzaali, M.J.*, Moosabeiki, V., Rajaei Harandi, S., Zhou, J., Zadpoor, A.A.
Materials 15(15), 5457 (2022)

Comprehensive review of design principles for additive manufacturing of biomaterials across metals, polymers, and ceramics. Covers library-based design, topology optimisation, bioinspired design, and meta-biomaterials. One of the most-cited and most-viewed review articles in the journal.

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Ultra-programmable buckling-driven soft cellular mechanisms Open Access
Janbaz, S., Bobbert, F.S.L., Mirzaali, M.J., Zadpoor, A.A.
Materials Horizons 6, 1138–1147 (2019)

Multi-material buckling-driven metamaterials with high programmability, demonstrating double-side buckling modes alongside conventional instability modes. Applications include force switches, kinematic controllers, and pick-and-place end-effectors for soft robotics. Featured by the Royal Society of Chemistry.

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Action-at-a-distance metamaterials: Distributed local actuation through far-field global forces Open Access
Hedayati, R., Mirzaali, M.J., Vergani, L., Zadpoor, A.A.
APL Materials 6, 036101 (2018)

Introduction of 3D-printable "action-at-a-distance" metamaterials using combinations of honeycomb and bow-tie (auxetic) cellular structures to create soft actuators with complex actuation patterns from a single far-field force. Potential applications in wearable soft robotics. Featured in 3DPrint.com.

View All Publications on Google Scholar

Our Lab Members

A multidisciplinary group of researchers working at the frontiers of biomechanics, materials science, and biomedical engineering.

Current Members

Alumni — PhD Graduates

Visiting Scholars

MSc Students & Theses Supervised

Current MSc Students (TUDelft)

Matisse Laurens
"3D printing of soft tissue"
2026–present
Rwan Ahmed
MSc Thesis
2026–present
Thom de Bruijn
MSc Thesis
2026–present
Mieke Steijger
MSc Thesis
May 2026–present
Francesca Pachin (Visiting Master Student)
MSc Thesis
2026–present
Former MSc Theses — TUDelft (30+ completed) ▼ expand
F. Mule (2026)
"The effect of Poisson's ratio and cellulose nanocrystals on mouse pre-osteoblasts"
2026
S. Dong
"Developing and 3D Printing of Ceramic–Hydrogel and Metal–Hydrogel Inks for Bone-to-Soft Tissue Transition Zone Scaffolds"
2025
H. den Hertog
"Development and Validation of an Automatic Pre-Surgical Planning Tool for Long Bone Osteotomy"
2025
C.H.Y. Low
"Improving Comfort for Transtibial Socket Users"
2025
P.C.W.M. van der Valk
"Reinforcement Learning-Based Path Planning for Additive Manufacturing of Homogenised Grid Structures"
2025
G. Szigetvári
"Design, Modelling and Experimental Validation of Fluidically Actuated Soft Metamaterials"
2025
L.P. d'Engelbronner
"Design and Manufacturing of a Novel Experimental Setup for Evaluating Mandibular Reconstructive Implants"
2025
E. Çinar San Segundo
"Multi-material 4D-printing of a Magneto-responsive Hydrogel Scaffold with Tuned Stiffness"
2024
Ricci, G.
"Engineering Hard-Soft Interfaces: Insights from Root-Soil Interaction"
Sep 2023–Dec 2024
Vannucci, M.
"Hybrid metamaterials in the design of mandibular implants"
Sep 2023–Aug 2024
San Segundu, E.
"Multi-material 4D-printing of a magneto-responsive hydrogel scaffold"
Sep 2023–Aug 2024
Arias, S.
"Knowledge-based design integration in smart prosthetic socket"
Sep 2023–Aug 2024
Cussen, K.
"Micro-4D printed medical devices"
Sep 2023–Apr 2024
Zwart, M.
"Functionally Graded 3D-Printed Scaffolds via Direct Ink Writing"
Sep 2023–Mar 2024
Ferilli, L.
"Influence of model parameters in FE model of a TAVI valve"
Sep 2022–Apr 2025
van Tunen, R.
"Computational Predictive Modeling of a Novel Pulmonary Valved Conduit"
Sep 2022–Nov 2023
Mubeen, A.A.
"Two-Photon Polymerization 4D Printing of Mechanical Metamaterials"
Sep 2022–Aug 2023
Tay, E.
"A Bone Remodelling Approach For Biphasic Metamaterial Optimisation"
Sep 2021–Aug 2022
Wu, C.
"Bending- and stretching-dominated metamaterials"
Sep 2021–May 2022
Troost, L.
"Transtibial prosthesis with temperature and pressure sensory systems"
Sep 2020–Apr 2022
de Winter, N.
"Design of patient-specific orthopedic plate for proximal femur fixation"
Sep 2021–May 2022
Fokker, M.
"Development of crumpled-based meta-biomaterials as bone filling substitutes"
Sep 2018–Jun 2022
van Kootwijk, A.
"Workflow for designing patient-specific mandibular reconstruction implants"
Sep 2020–Sep 2021
Cazier, J.
"Morphological and mechanical assessment of osteochondral unit"
Sep 2019–Sep 2023
Veeger, R.
"Nano-indentation of functionally graded composites"
Sep 2019–Oct 2021
Pitta Kruiz, C.
"3D printing of metal-polymer interface"
Sep 2019–Sep 2021
Khan, A.
"Design and multi-material additive manufacturing of functionally graded fracture fixation plate"
Sep 2019–Sep 2023
Tsifoutis Kazolis, K.
"Patient-specific 3D-printed scoliosis braces"
Aug 2019–Aug 2022
Peeters, D.
"Auxetic/non-auxetic 3D scaffold for bone tissue regeneration"
Sep 2019–Nov 2020
Gkoni, I.
"Large bone-implants for osteochondral regeneration, fabrication and ex-vivo testing"
Jan 2019–Oct 2020
Dimaraki, A.
"3D bioprinting of cartilage"
Jun 2019–Jul 2020
Oldhoff, M.
"Patient-specific 3D-printed temporomandibular joints (TMJ)"
Jan 2019–Dec 2019
Gunashekar, D.
"Multiscale anisotropic architecture in bio-inspired materials"
Jun 2018–Aug 2019
Herranz de la Nava, A.
"Voxel-based additive manufacturing of biomimetic functionally graded materials"
Jan–Nov 2018
Cruz Saldivar, M.
"Bone ingrowth and medial tibial collapse analysis using FEM"
Feb–Sep 2018
Guvenir, S.
"Glaucomatous rat eye optic nerve head biomechanics with FEM"
Feb–Sep 2018
Edens, M.
"Voxel-based additive manufacturing of biomimetic hard-soft materials"
Sep–Jun 2018
Former MSc Theses — Joint & International Programs ▼ expand
Carbini, M.
"Enhancing toughness and fatigue life of Hard-Soft Interfaces via FGM"
May–Sep 2022
Limuti, M.
"Rate-dependent mechanical meta-materials"
May–Sep 2022
Ghalayani, A.
"Programming single and multi-material 4D printed structures"
Aug 2020–Jun 2021
Abaeian, A.
"Buckling analysis of mechanical metamaterials"
Aug 2019–Jun 2020
Amani, M.
"Patient-specific 3D printing of transtibial socket prosthesis"
Jul 2019–Jun 2020
Trabattoni, E.
"Multi-material 3D printing of torsion-resistance biomimetic composites"
Jun–Nov 2019
Tonarelli, G.
"FE modeling of biomimetic torsion-resistance composites"
Jun–Nov 2019
Caracciolo, A.
"Dual-phase interaction of metamaterials with superimposed shapes"
Jun–Nov 2018
E. Bilgich
"Single cell printing"
Oct 2024–present
S. Matteucci
"3D printing of wood-based materials"
Sep 2024–present
Singanamalla, H. (POLIMI)
"Numerical analysis of trabecular bone using voxel-based model"
May 2017–Apr 2018
Bouwakdh, F. (POLIMI)
"Effect of mechanical properties' distribution on porcine trabecular bone"
Oct 2017–Feb 2018
Böhm, C. (POLIMI)
"Effects of fatigue loading on trabecular bone"
May–Oct 2017
Ferrario, D. (POLIMI)
"Effect of morphological and clinical parameters on damage accumulation in porcine trabecular bone"
Jul 2016–Apr 2017
Browse All MSc Theses in TU Delft Repository

News & Highlights

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bio-TIE Lab

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Address
Department of Biomechanical Engineering
TU Delft, Office 34 E-3-210
Mekelweg 2, 2628 CD Delft, The Netherlands
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